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The lead-in dosing with 200 mg once-daily immediate-release viramune should not be continued beyond 28 days, at which point an alternative regimen should be sought.

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Granulocytopenia is commonly associated with zidovudineThereforepatients who receive nevirapine and zidovudine concomitantly and especially paediatric patients and patients who receive higher zidovudine doses or patients with poor bone marrow reservein particular those with advanced HIV diseasehave an increased risk of granulocytopeniaIn such patients haematological parameters should be carefully monitored.

Patients with rare hereditary problems of galactose intolerance e.ggalactosaemiathe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Potentially fatal hepatotoxicityfulminant hepatitischolestatic hepatitishepatic failurehepatic necrosis)

Caution should be exercised when co-administering telaprevir with nevirapine.

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