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TABLE 5Effect of Ezetimibe Coadministration on Systemic Exposure to Other Drugs.

Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compoundsstatinsbile acid sequestrantsresinsfibric acid derivativesand plant stanolsThe molecular target of ezetimibe has been shown to be the sterol transporterNiemann-Pick C1-Like 1NPC1L1which is involved in the intestinal uptake of cholesterol and phytosterols.

Because the reactions below are reported voluntarily from a population of uncertain sizeit is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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