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Zyloprim generic name allopurinol pronounced al oh pure i nole – tablet, powder for injection.

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Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.

Chlorpropamide’s plasma half-life may be prolonged by Zyloprimsince Zyloprim and chlorpropamide may compete for excretion in the renal tubuleThe risk of hypoglycemia secondary to this mechanism may be increased if Zyloprim and chlorpropamide are given concomitantly in the presence of renal insufficiency.

Gout is a metabolic disorder which is characterized by hyperuricemia and resultant deposition of monosodium urate in the tissuesparticularly the joints and kidneysThe etiology of this hyperuricemia is the overproduction of uric acid in relation to the patient’s ability to excrete itIf progressive deposition of urates is to be arrested or reversedit is necessary to reduce the serum uric acid level below the saturation point to suppress urate precipitation.

The reports that the concomitant use of Zyloprim and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causationReview of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests canadian pharmacies safe. to rule out decreased renal function secondary to hypertensive nephropathy were not often performedIn those patients in whom renal insufficiency was documentedhoweverthe recommendation to lower the dose of Zyloprim was not followedAlthough a causal mechanism and a cause-and-effect relationship have not been establishedcurrent evidence suggests that renal function should be monitored in patients on thiazide diuretics and Zyloprim even in the absence of renal failureand dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.

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